Scientific Context: Understanding which host genes and pathways enable SARS-CoV-2 to infect human cells is crucial for developing targeted therapies and improving our response to COVID-19. This study set out to systematically dissect the molecular interactions that make certain cells susceptible to viral entry and replication.

How were 10x Genomics' products used?

Researchers applied the 10x Genomics Chromium Single Cell platform to profile gene expression in thousands of individual human cells exposed to SARS-CoV-2. This high-throughput, single-cell RNA sequencing approach enabled the team to:

• Capture the diversity of cellular responses to infection.
• Pinpoint host genes and pathways that are essential for viral entry and replication.
• Map out the molecular landscape of infected versus uninfected cells at unprecedented resolution.

Impact: 10x Genomics technology was critical in revealing the cellular gatekeepers of SARS-CoV-2 infection. These insights not only deepen our understanding of COVID-19 pathogenesis but also identify promising targets for antiviral drug development and therapeutic intervention. This work sets a new standard for infectious disease research using single-cell genomics.

BonsaiLab: Your 10x Genomics Partner in Spain and Portugal

As the official distributor of 10x Genomics in Spain and Portugal, BonsaiLab is ready to help you leverage single-cell and spatial genomics in your infectious disease research.

Contact us and let's arrange a meeting!

Curious to learn more?
Read the full study here