Excited to share a landmark study that leveraged 10x Genomics technologies to unravel the cellular architecture and immune landscape of human cutaneous squamous cell carcinoma (cSCC).
"Multimodal Analysis of Composition and Spatial Architecture in Human Squamous Cell Carcinoma"
How did 10x Genomics power this research study?
- Chromium Single Cell Analysis: Enabled high-throughput single-cell RNA sequencing (scRNA-seq) of over 48,000 cells from tumors and matched normal skin. This allowed researchers to capture the diversity of cell types and states, identify both normal and tumor-specific keratinocyte populations, and profile immune and stromal cells at single-cell resolution.
- Visium Spatial Transcriptomics: Provided spatial transcriptomics by mapping gene expression to precise locations within tumor tissue sections. This technology revealed spatial heterogeneity, visualized the organization of cell populations (including a unique tumor-specific keratinocyte population at the tumor's leading edge), and helped link gene expression patterns to specific microenvironmental niches.
- Impact on the Research: By integrating single-cell and spatial data, the study mapped complex cell-cell interactions and identified key gene networks driving tumor progression and immune evasion. This comprehensive atlas advances our understanding of cancer biology and highlights new therapeutic targets.
BonsaiLab: Your 10x Genomics Partner in Spain and Portugal
BonsaiLab is the official distributor of 10x Genomics solutions in Spain and Portugal. If you're interested in bringing their tech into your research, our expert team is here to help.
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Curious to learn more?
Read the full study here.