{"id":48187,"date":"2025-10-14T08:50:31","date_gmt":"2025-10-14T06:50:31","guid":{"rendered":"https:\/\/bonsailab.com\/?p=48187"},"modified":"2025-10-15T09:16:27","modified_gmt":"2025-10-15T07:16:27","slug":"single-cell-genomics-sars-cov2-host-factors","status":"publish","type":"post","link":"https:\/\/bonsailab.com\/pt-pt\/single-cell-genomics-sars-cov2-host-factors\/","title":{"rendered":"Unraveling COVID-19: Single-Cell Genomics Reveals Host Factors for SARS-CoV-2 Infection"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-top:30px;--awb-padding-bottom:20px;--awb-margin-top:49.9965px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1144px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1 blogintro\" style=\"--awb-font-size:16px;--awb-text-color:#001847;--awb-margin-right:50px;--awb-margin-left:50px;\"><p>We&#8217;re excited to spotlight a landmark study that leveraged 10x Genomics single-cell technology to identify the key human cell factors required for SARS-CoV-2 infection.<\/p>\n<\/div><div class=\"fusion-text fusion-text-2\" style=\"--awb-font-size:16px;--awb-text-color:#001847;--awb-margin-right:50px;--awb-margin-left:50px;\" id=\"blog-block\"><p><strong>Scientific Context:<\/strong> Understanding which host genes and pathways enable SARS-CoV-2 to infect human cells is crucial for developing targeted therapies and improving our response to COVID-19. This study set out to systematically dissect the molecular interactions that make certain cells susceptible to viral entry and replication.<\/p>\n<h2><strong>How were 10x Genomics&#8217; products used?<\/strong><\/h2>\n<p>Researchers applied the 10x Genomics Chromium Single Cell platform to profile gene expression in thousands of individual human cells exposed to SARS-CoV-2. This high-throughput, single-cell RNA sequencing approach enabled the team to:<\/p>\n<ul>\n<li>Capture the diversity of cellular responses to infection.<\/li>\n<li>Pinpoint host genes and pathways that are essential for viral entry and replication.<\/li>\n<li>Map out the molecular landscape of infected versus uninfected cells at unprecedented resolution.<\/li>\n<\/ul>\n<p><strong>Impact:<\/strong> 10x Genomics technology was critical in revealing the cellular gatekeepers of SARS-CoV-2 infection. These insights not only deepen our understanding of COVID-19 pathogenesis but also identify promising targets for antiviral drug development and therapeutic intervention. This work sets a new standard for infectious disease research using single-cell genomics.<\/p>\n<\/div><div class=\"fusion-image-element \" style=\"text-align:center;--awb-max-width:500px;--awb-caption-title-font-family:var(--h2_typography-font-family);--awb-caption-title-font-weight:var(--h2_typography-font-weight);--awb-caption-title-font-style:var(--h2_typography-font-style);--awb-caption-title-size:var(--h2_typography-font-size);--awb-caption-title-transform:var(--h2_typography-text-transform);--awb-caption-title-line-height:var(--h2_typography-line-height);--awb-caption-title-letter-spacing:var(--h2_typography-letter-spacing);\"><span class=\" fusion-imageframe imageframe-none imageframe-1 hover-type-none\"><img decoding=\"async\" width=\"664\" height=\"664\" title=\"SARS-CoV-2-fx1_lrg\" src=\"https:\/\/bonsailab.com\/wp-content\/uploads\/2025\/10\/SARS-CoV-2-fx1_lrg.jpg\" alt class=\"img-responsive wp-image-48190\" srcset=\"https:\/\/bonsailab.com\/wp-content\/uploads\/2025\/10\/SARS-CoV-2-fx1_lrg-200x200.jpg 200w, https:\/\/bonsailab.com\/wp-content\/uploads\/2025\/10\/SARS-CoV-2-fx1_lrg-400x400.jpg 400w, https:\/\/bonsailab.com\/wp-content\/uploads\/2025\/10\/SARS-CoV-2-fx1_lrg-600x600.jpg 600w, https:\/\/bonsailab.com\/wp-content\/uploads\/2025\/10\/SARS-CoV-2-fx1_lrg.jpg 664w\" sizes=\"(max-width: 1024px) 100vw, (max-width: 640px) 100vw, 664px\" \/><\/span><\/div><div class=\"fusion-text fusion-text-3\" style=\"--awb-font-size:16px;--awb-text-color:#001847;--awb-margin-right:50px;--awb-margin-left:50px;\" id=\"blog-block\"><h2><strong>BonsaiLab: Your 10x Genomics Partner in Spain and Portugal<\/strong><\/h2>\n<p>As the official distributor of 10x Genomics in Spain and Portugal, BonsaiLab is ready to help you leverage single-cell and spatial genomics in your infectious disease research.<\/p>\n<p>Contact us and let\u2019s arrange a meeting!<\/p>\n<p>Curious to learn more?<br \/>\nRead the full study <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33147445\/\">here<\/a><\/p>\n<\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div style=\"text-align:center;\"><a class=\"fusion-button button-flat button-medium button-custom fusion-button-default button-1 fusion-button-default-span fusion-button-default-type fusion-has-button-gradient\" 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fusion-content-layout-column\"><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":48192,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[194,195,196,253,256],"tags":[],"class_list":["post-48187","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad-pt-pt","category-apoyo-cientifico-pt-pt","category-genomica-pt-pt","category-10xgenomics-pt-pt","category-investigacion"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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