{"id":42406,"date":"2025-02-24T11:47:38","date_gmt":"2025-02-24T11:47:38","guid":{"rendered":"https:\/\/bonsailab.com\/los-beneficios-de-la-secuenciacion-de-celulas-individuales-descubriendo-los-secretos-de-la-biologia-celular-2\/"},"modified":"2025-08-28T10:48:56","modified_gmt":"2025-08-28T10:48:56","slug":"the-billion-cells-project-advancing-ai-in-biology-with-unprecedented-single-cell-data","status":"publish","type":"post","link":"https:\/\/bonsailab.com\/pt-pt\/the-billion-cells-project-advancing-ai-in-biology-with-unprecedented-single-cell-data\/","title":{"rendered":"The billion cells project: advancing AI in biology with unprecedented single-cell data"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1144px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:0px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1 blogintro\"><p>In a groundbreaking move for the scientific community, the Chan Zuckerberg Initiative (CZI) has launched the billion cells project, an ambitious effort to generate an unprecedented dataset of one billion single cells. This massive dataset will fuel advancements in AI-driven biological research, enabling scientists to gain deeper insights into cellular behavior and gene function.<\/p>\n<\/div><div class=\"fusion-text fusion-text-2\"><h3>A collaboration to transform biology<\/h3>\n<p>CZI has partnered with 10x Genomics, Ultima Genomics, and leading researchers to make this vision a reality. By leveraging cutting-edge technologies and optimizing cost efficiencies, this initiative aims to provide a comprehensive and standardized resource for researchers worldwide. The scale and quality of data generated will surpass previous efforts, facilitating the development of AI models that can drive transformative discoveries in precision medicine, functional genomics, and disease research.<\/p>\n<h3>Why does this matter?<\/h3>\n<p>The billion cells project is poised to impact multiple domains of biology by:<\/p>\n<ul>\n<li>Mapping genetic perturbations across diverse cell types and tissues.<\/li>\n<li>Enabling AI models to uncover hidden patterns in cellular behavior.<\/li>\n<li>Accelerating research in disease mechanisms and potential therapeutic targets.<\/li>\n<li>Standardizing large-scale single-cell datasets for global accessibility.<\/li>\n<\/ul>\n<blockquote>\n<p>\u201cBiology not only needs more data \u2013 it needs data faster and in interoperable formats to support AI models that address specific problems,\u201d said Jonah Cool, Cell Science Senior Science Program Officer at CZI. \u201cThis project represents a unique approach to scaling and standardizing scientific outputs for AI and more.\u201d<\/p>\n<\/blockquote>\n<h3>Leveraging state-of-the-art technologies<\/h3>\n<p>The project will utilize 10x Genomics\u2019 Chromium GEM-X technology, which delivers higher sensitivity, improved throughput, and superior data quality for large-scale single-cell analysis. Sequencing will be conducted using Ultima Genomics\u2019 UG 100\u2122 platform, an ultra-high throughput next-generation sequencing system designed to enable massive-scale genomic data generation at lower costs.<\/p>\n<p>By integrating these advanced technologies, the initiative will generate datasets with unmatched depth, resolution, and accuracy, offering researchers new opportunities to explore gene regulation, immune response, and the fundamental mechanisms driving human biology.<\/p>\n<h3>Open science for global impact<\/h3>\n<p>CZI remains committed to the principles of open science, ensuring that the billion cells project\u2019s results will be made freely available to the global scientific community. The generated data will be used to train virtual cell models on CZI\u2019s powerful computing infrastructure, enhancing the ability of researchers worldwide to unlock new discoveries in human health and disease.<\/p>\n<blockquote>\n<p>\u201cThis project will provide the necessary scale of data to understand the functional effects of human genetic variants and characterize the genetic drivers of disease,\u201d said Alexander Marson, Director of the Gladstone-UCSF Institute of Genomic Immunology. \u201cUltimately, the billion cells project will serve as a functional roadmap for drug development, identifying key targets to restore diseased cells to health.\u201d<\/p>\n<\/blockquote>\n<h3>The future of AI-powered biology<\/h3>\n<p>The billion cells project represents a significant leap forward in the convergence of artificial intelligence and biology. As additional industry and academic collaborations emerge, this initiative will continue to expand the possibilities for single-cell research, precision medicine, and functional genomics.<\/p>\n<p>With the power of AI, scalable genomics, and open-access data, the billion cells project is set to redefine the boundaries of what\u2019s possible in life sciences research. The future of biology is data-driven\u2014and this project is paving the way for groundbreaking discoveries.<\/p>\n<p>Stay tuned for more updates as this transformative initiative unfolds!<\/p>\n<\/div><div style=\"text-align:center;\"><a class=\"fusion-button button-flat fusion-button-default-size button-custom fusion-button-default button-1 fusion-button-default-span fusion-button-default-type fusion-has-button-gradient\" style=\"--button_accent_color:#ffffff;--button_accent_hover_color:#010051;--button_border_hover_color:#010051;--button-border-radius-top-left:8px;--button-border-radius-top-right:8px;--button-border-radius-bottom-right:8px;--button-border-radius-bottom-left:8px;--button_gradient_angle:180deg;--button_gradient_top_color:#00bbff;--button_gradient_bottom_color:#003372;--button_gradient_top_color_hover:#e0fff9;--button_gradient_bottom_color_hover:rgba(255,255,255,0.64);--button_typography-font-family:&quot;Montserrat&quot;;--button_typography-font-style:normal;--button_typography-font-weight:400;\" target=\"_blank\" rel=\"noopener noreferrer\" data-hover=\"icon_slide\" href=\"https:\/\/investors.10xgenomics.com\/news\/news-details\/2025\/Chan-Zuckerberg-Initiative-Launches-Billion-Cells-Project-with-10x-Genomics-and-Ultima-Genomics-to-Advance-AI-in-Biology-2025-TybuZlLBXI\/default.aspx\"><i class=\"fa-info-circle fas awb-button__icon awb-button__icon--default button-icon-left\" aria-hidden=\"true\"><\/i><span class=\"fusion-button-text awb-button__text awb-button__text--default\">More info<\/span><\/a><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":6,"featured_media":42408,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_bbp_topic_count":0,"_bbp_reply_count":0,"_bbp_total_topic_count":0,"_bbp_total_reply_count":0,"_bbp_voice_count":0,"_bbp_anonymous_reply_count":0,"_bbp_topic_count_hidden":0,"_bbp_reply_count_hidden":0,"_bbp_forum_subforum_count":0,"rs_blank_template":"","rs_page_bg_color":"","slide_template_v7":"","footnotes":""},"categories":[194,195,196,253],"tags":[],"class_list":["post-42406","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualidad-pt-pt","category-apoyo-cientifico-pt-pt","category-genomica-pt-pt","category-10xgenomics-pt-pt"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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